Ontology highlight
ABSTRACT:
SUBMITTER: Logan SL
PROVIDER: S-EPMC5910850 | biostudies-other | 2018 Apr
REPOSITORIES: biostudies-other
Logan Savannah L SL Thomas Jacob J Yan Jinyuan J Baker Ryan P RP Shields Drew S DS Xavier Joao B JB Hammer Brian K BK Parthasarathy Raghuveer R
Proceedings of the National Academy of Sciences of the United States of America 20180402 16
Host-associated microbiota help defend against bacterial pathogens; however, the mechanisms by which pathogens overcome this defense remain largely unknown. We developed a zebrafish model and used live imaging to directly study how the human pathogen <i>Vibrio cholerae</i> invades the intestine. The gut microbiota of fish monocolonized by symbiotic strain <i>Aeromonas veronii</i> was displaced by <i>V. cholerae</i> expressing its type VI secretion system (T6SS), a syringe-like apparatus that dep ...[more]