Ontology highlight
ABSTRACT:
SUBMITTER: Xu WJ
PROVIDER: S-EPMC5910857 | biostudies-other | 2018 Apr
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20180402 16
Recent studies point out the link between altered mitochondrial metabolism and cancer, and detailed understanding of mitochondrial metabolism requires real-time detection of its metabolites. Employing heteronuclear 2D NMR spectroscopy and <sup>13</sup>C<sub>3</sub>-pyruvate, we propose in-organelle metabolomics that allows for the monitoring of mitochondrial metabolic changes in real time. The approach identified acetyl phosphate from human mitochondria, whose production has been largely neglect ...[more]