High fat diet induces airway hyperresponsiveness in mice.
Ontology highlight
ABSTRACT:
SUBMITTER: Fricke K
PROVIDER: S-EPMC5913253 | biostudies-other | 2018 Apr
REPOSITORIES: biostudies-other
Publications
High fat diet induces airway hyperresponsiveness in mice.
Fricke Kathrin K Vieira Marcela M Younas Haris H Shin Mi-Kyung MK Bevans-Fonti Shannon S Berger Slava S Lee Rachel R D'Alessio Franco R FR Zhong Qiong Q Nelson Andrew A Loube Jeff J Sanchez Ian I Hansel Nadia N NN Mitzner Wayne W Polotsky Vsevolod Y VY
Scientific reports 20180423 1
The experiment was conducted to examine the effect of a high fat diet (HFD) on airway hyperresponsiveness (AHR) in mice. Twenty-three adult male C57BL/6 J mice were fed with HFD or regular chow diet for two weeks. The total respiratory resistance was measured by forced oscillation technique at baseline and after methacholine aerosol challenge at 1, 3, 10 and 30 mg/mL. Bronchoalveolar lavage (BAL) was performed. Lipid levels and lipid peroxidation in lung tissue were measured along with gene expr ...[more]
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