Ontology highlight
ABSTRACT:
SUBMITTER: Emoto C
PROVIDER: S-EPMC5915605 | biostudies-other | 2018 Apr
REPOSITORIES: biostudies-other
Emoto Chie C Johnson Trevor N TN McPhail Brooks T BT Vinks Alexander A AA Fukuda Tsuyoshi T
CPT: pharmacometrics & systems pharmacology 20180215 4
Simultaneous changes in several physiological factors may contribute to the large pharmacokinetic (PK) variability of vancomycin. This study was designed to systematically characterize the effects of multiple physiological factors to the altered PK of vancomycin observed in special populations. A vancomycin physiologically based pharmacokinetic (PBPK) model was developed as a PK simulation platform to quantitatively assess the effects of changes in physiologies to the PK profiles. The developed ...[more]