Ontology highlight
ABSTRACT:
SUBMITTER: Giri SS
PROVIDER: S-EPMC5915799 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Giri Sovan Sundar SS Liu Rai-Shung RS
Chemical science 20180219 11
New gold-catalyzed [4+3]-annulations of 3-en-1-ynamides with isoxazoles afford 4<i>H</i>-azepines efficiently; this process involves 6π electrocyclizations of gold-stabilized 3-azaheptatrienyl cations. In the presence of Zn(OTf)<sub>2</sub>, the resulting 4<i>H</i>-azepines undergo skeletal rearrangement to furnish substituted pyridine derivatives. We subsequently develop new catalytic [4+2]-annulations between the same 3-en-1-ynamides and isoxazoles to deliver substituted pyridine products usin ...[more]