Ontology highlight
ABSTRACT:
SUBMITTER: Ferrando-Martinez S
PROVIDER: S-EPMC5919804 | biostudies-other | 2018 May
REPOSITORIES: biostudies-other
The Journal of clinical investigation 20180416 5
LN follicles constitute major reservoir sites for HIV/SIV persistence. Cure strategies could benefit from the characterization of CD8+ T cells able to access and eliminate HIV-infected cells from these areas. In this study, we provide a comprehensive analysis of the phenotype, frequency, localization, and functionality of follicular CD8+ T cells (fCD8+) in SIV-infected nonhuman primates. Although disorganization of follicles was a major factor, significant accumulation of fCD8+ cells during chro ...[more]