Ontology highlight
ABSTRACT:
SUBMITTER: Ryu JC
PROVIDER: S-EPMC5919823 | biostudies-other | 2018 May
REPOSITORIES: biostudies-other
Ryu Jae Cheon JC Tooke Katharine K Malley Susan E SE Soulas Anastasia A Weiss Tirzah T Ganesh Nisha N Saidi Nabila N Daugherty Stephanie S Saragovi Uri U Ikeda Youko Y Zabbarova Irina I Kanai Anthony J AJ Yoshiyama Mitsuharu M Farhadi H Francis HF de Groat William C WC Vizzard Margaret A MA Yoon Sung Ok SO
The Journal of clinical investigation 20180326 5
Loss of bladder control is a challenging outcome facing patients with spinal cord injury (SCI). We report that systemic blocking of pro-nerve growth factor (proNGF) signaling through p75 with a CNS-penetrating small-molecule p75 inhibitor resulted in significant improvement in bladder function after SCI in rodents. The usual hyperreflexia was attenuated with normal bladder pressure, and automatic micturition was acquired weeks earlier than in the controls. The improvement was associated with inc ...[more]