Ontology highlight
ABSTRACT:
SUBMITTER: Zeng B
PROVIDER: S-EPMC5919883 | biostudies-other | 2018 May
REPOSITORIES: biostudies-other
Zeng Bijun B Middelberg Anton Pj AP Gemiarto Adrian A MacDonald Kelli K Baxter Alan G AG Talekar Meghna M Moi Davide D Tullett Kirsteen M KM Caminschi Irina I Lahoud Mireille H MH Mazzieri Roberta R Dolcetti Riccardo R Thomas Ranjeny R
The Journal of clinical investigation 20180409 5
Non-antigen-specific stimulatory cancer immunotherapies are commonly complicated by off-target effects. Antigen-specific immunotherapy, combining viral tumor antigen or personalized neoepitopes with immune targeting, offers a solution. However, the lack of flexible systems targeting tumor antigens to cross-presenting dendritic cells (DCs) limits clinical development. Although antigen-anti-Clec9A mAb conjugates target cross-presenting DCs, adjuvant must be codelivered for cytotoxic T lymphocyte ( ...[more]