Ontology highlight
ABSTRACT:
SUBMITTER: Orfali RL
PROVIDER: S-EPMC5923268 | biostudies-other | 2018 Apr
REPOSITORIES: biostudies-other
Orfali Raquel Leao RL da Silva Oliveira Luanda Mara LM de Lima Josenilson Feitosa JF de Carvalho Gabriel Costa GC Ramos Yasmim Alefe Leuzzi YAL Pereira Natalli Zanete NZ Pereira Naiura Vieira NV Zaniboni Mariana Colombini MC Sotto Mirian Nacagami MN da Silva Duarte Alberto José AJ Sato Maria Notomi MN Aoki Valeria V
Scientific reports 20180427 1
Atopic dermatitis (AD) is a chronic inflammatory immune-mediated skin disease characterized by skin colonization by Staphylococcus aureus. Interleukin (IL)-22, in cooperation with IL-17, triggers antimicrobial peptide elaboration and enhances certain immunological responses. In AD, IL-22 is related to epidermal hyperplasia, keratinocyte apoptosis, and inhibition of antimicrobial peptide (AMP) production. We aimed to evaluate the impact of staphylococcal enterotoxins on the Tc22/Th22 induction in ...[more]