Ontology highlight
ABSTRACT:
SUBMITTER: Gokey JJ
PROVIDER: S-EPMC5926907 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Gokey Jason J JJ Sridharan Anusha A Xu Yan Y Green Jenna J Carraro Gianni G Stripp Barry R BR Perl Anne-Karina T AT Whitsett Jeffrey A JA
JCI insight 20180322 6
Hippo/YAP signaling plays pleiotropic roles in the regulation of cell proliferation and differentiation during organogenesis and tissue repair. Herein we demonstrate increased YAP activity in respiratory epithelial cells in lungs of patients with idiopathic pulmonary fibrosis (IPF), a common, lethal form of interstitial lung disease (ILD). Immunofluorescence staining in IPF epithelial cells demonstrated increased nuclear YAP and loss of MST1/2. Bioinformatic analyses of epithelial cell RNA profi ...[more]