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Pathological Margin Clearance and Survival After Pancreaticoduodenectomy in a US and European Pancreatic Center.

ABSTRACT: The optimal definition of a margin-negative resection and its exact prognostic significance on survival in resected pancreatic adenocarcinoma remains unknown. This study was designed to assess the relationship between pathological margin clearance, margin type, and survival.Patients who underwent pancreaticoduodenectomy with curative intent at two academic institutions, in Amsterdam, the Netherlands, and Boston, Massachusetts, between 2000 and 2014 were retrospectively evaluated. Overall survival, recurrence rates, and progression-free survival (PFS) were assessed by Kaplan-Meier estimates and multivariate Cox proportional hazards analysis, according to pathological margin clearance and type of margin involved.Of 531 patients identified, the median PFS was 12.9, 15.4, and 24.1 months, and the median overall survival was 17.4, 22.9, and 27.7 months for margin clearances of 0,?

SUBMITTER: van Roessel S 

PROVIDER: S-EPMC5928169 | biostudies-other | 2018 Jun

REPOSITORIES: biostudies-other

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Pathological Margin Clearance and Survival After Pancreaticoduodenectomy in a US and European Pancreatic Center.

van Roessel Stijn S   Kasumova Gyulnara G GG   Tabatabaie Omidreza O   Ng Sing Chau SC   van Rijssen L Bengt LB   Verheij Joanne J   Najarian Robert M RM   van Gulik Thomas M TM   Besselink Marc G MG   Busch Olivier R OR   Tseng Jennifer F JF  

Annals of surgical oncology 20180412 6

<h4>Background</h4>The optimal definition of a margin-negative resection and its exact prognostic significance on survival in resected pancreatic adenocarcinoma remains unknown. This study was designed to assess the relationship between pathological margin clearance, margin type, and survival.<h4>Methods</h4>Patients who underwent pancreaticoduodenectomy with curative intent at two academic institutions, in Amsterdam, the Netherlands, and Boston, Massachusetts, between 2000 and 2014 were retrosp  ...[more]