Dataset Information

Sensitivity, Specificity, and Public-Health Utility of Clinical Case Definitions Based on the Signs and Symptoms of Cholera in Africa.

ABSTRACT: During 2014, Africa reported more than half of the global suspected cholera cases. Based on the data collected from seven countries in the African Cholera Surveillance Network (Africhol), we assessed the sensitivity, specificity, and positive and negative predictive values of clinical cholera case definitions, including that recommended by the World Health Organization (WHO) using culture confirmation as the gold standard. The study was designed to assess results in real-world field situations in settings with recent cholera outbreaks or endemicity. From June 2011 to July 2015, a total of 5,084 persons with suspected cholera were tested for Vibrio cholerae in seven different countries of which 35.7% had culture confirmation. For all countries combined, the WHO case definition had a sensitivity = 92.7%, specificity = 8.1%, positive predictive value = 36.1%, and negative predictive value = 66.6%. Adding dehydration, vomiting, or rice water stools to the case definition could increase the specificity without a substantial decrease in sensitivity. Future studies could further refine our findings primarily by using more sensitive methods for cholera confirmation.

SUBMITTER: Nadri J

PROVIDER: S-EPMC5928804 | biostudies-other | 2018 Apr

REPOSITORIES: biostudies-other

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Sensitivity, Specificity, and Public-Health Utility of Clinical Case Definitions Based on the Signs and Symptoms of Cholera in Africa.

Nadri Johara J Sauvageot Delphine D Njanpop-Lafourcade Berthe-Marie BM Baltazar Cynthia S CS Banla Kere Abiba A Bwire Godfrey G Coulibaly Daouda D Kacou N'Douba Adele A Kagirita Atek A Keita Sakoba S Koivogui Lamine L Landoh Dadja E DE Langa Jose P JP Miwanda Berthe N BN Mutombo Ndongala Guy G Mwakapeje Elibariki R ER Mwambeta Jacob L JL Mengel Martin A MA Gessner Bradford D BD

The American journal of tropical medicine and hygiene 20180222 4

During 2014, Africa reported more than half of the global suspected cholera cases. Based on the data collected from seven countries in the African Cholera Surveillance Network (Africhol), we assessed the sensitivity, specificity, and positive and negative predictive values of clinical cholera case definitions, including that recommended by the World Health Organization (WHO) using culture confirmation as the gold standard. The study was designed to assess results in real-world field situations i ...[more]

PMID: 29488455

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Dataset Information

Sensitivity, Specificity, and Public-Health Utility of Clinical Case Definitions Based on the Signs and Symptoms of Cholera in Africa.

Publications

Sensitivity, Specificity, and Public-Health Utility of Clinical Case Definitions Based on the Signs and Symptoms of Cholera in Africa.

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