Ontology highlight
ABSTRACT:
SUBMITTER: Brauning B
PROVIDER: S-EPMC5935710 | biostudies-other | 2018 May
REPOSITORIES: biostudies-other
Bräuning Bastian B Bertosin Eva E Praetorius Florian F Ihling Christian C Schatt Alexandra A Adler Agnes A Richter Klaus K Sinz Andrea A Dietz Hendrik H Groll Michael M
Nature communications 20180504 1
Pore-forming toxins (PFT) are virulence factors that transform from soluble to membrane-bound states. The Yersinia YaxAB system represents a family of binary α-PFTs with orthologues in human, insect, and plant pathogens, with unknown structures. YaxAB was shown to be cytotoxic and likely involved in pathogenesis, though the molecular basis for its two-component lytic mechanism remains elusive. Here, we present crystal structures of YaxA and YaxB, together with a cryo-electron microscopy map of t ...[more]