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Expression Profiling Analysis Reveals Key MicroRNA-mRNA Interactions in Early Retinal Degeneration in Retinitis Pigmentosa.

ABSTRACT: The aim of this study was to identify differentially expressed microRNAs (miRNAs) that might play an important role in the etiology of retinal degeneration in a genetic mouse model of retinitis pigmentosa (rd10 mice) at initial stages of the disease.miRNAs-mRNA interaction networks were generated for analysis of biological pathways involved in retinal degeneration.Of more than 1900 miRNAs analyzed, we selected 19 miRNAs on the basis of (1) a significant differential expression in rd10 retinas compared with control samples and (2) an inverse expression relationship with predicted mRNA targets involved in biological pathways relevant to retinal biology and/or degeneration. Seven of the selected miRNAs have been associated with retinal dystrophies, whereas, to our knowledge, nine have not been previously linked to any disease.This study contributes to our understanding of the etiology and progression of retinal degeneration.

SUBMITTER: Anasagasti A 

PROVIDER: S-EPMC5939684 | biostudies-other | 2018 May

REPOSITORIES: biostudies-other

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Expression Profiling Analysis Reveals Key MicroRNA-mRNA Interactions in Early Retinal Degeneration in Retinitis Pigmentosa.

Anasagasti Ander A   Ezquerra-Inchausti Maitane M   Barandika Olatz O   Muñoz-Culla Maider M   Caffarel María M MM   Otaegui David D   López de Munain Adolfo A   Ruiz-Ederra Javier J  

Investigative ophthalmology & visual science 20180501 6

<h4>Purpose</h4>The aim of this study was to identify differentially expressed microRNAs (miRNAs) that might play an important role in the etiology of retinal degeneration in a genetic mouse model of retinitis pigmentosa (rd10 mice) at initial stages of the disease.<h4>Methods</h4>miRNAs-mRNA interaction networks were generated for analysis of biological pathways involved in retinal degeneration.<h4>Results</h4>Of more than 1900 miRNAs analyzed, we selected 19 miRNAs on the basis of (1) a signif  ...[more]

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