Ontology highlight
ABSTRACT:
SUBMITTER: Kim JE
PROVIDER: S-EPMC5945848 | biostudies-other | 2018 May
REPOSITORIES: biostudies-other
Kim Ji-Eun JE Ko Ah-Reum AR Hyun Hye-Won HW Min Su-Ji SJ Kang Tae-Cheon TC
Cell death & disease 20180501 5
Recently, we have reported that heat shock protein B1 (HSPB1) and purinergic receptor P2X7 (P2RX7) are involved in astroglial autophagy (clasmatodendrosis), following status epilepticus (SE). However, the underlying mechanisms of astroglial autophagy have not been completely established. In the present study, we found that the lacking of P2rx7 led to prolonged astroglial HSPB1 induction due to impaired mitogen-activated protein kinase 1/2 (MAPK1/2)-mediated specificity protein 1 (SP1) phosphoryl ...[more]