Ontology highlight
ABSTRACT:
SUBMITTER: Martinez-Grau MA
PROVIDER: S-EPMC5946847 | biostudies-other | 2018 Jun
REPOSITORIES: biostudies-other
Martinez-Grau Maria Angeles MA Valcarcel Isabel C Gonzalez ICG Early Julie V JV Gessner Richard Klaus RK de Melo Candice Soares CS de la Nava Eva Maria Martin EMM Korkegian Aaron A Ovechkina Yulia Y Flint Lindsay L Gravelle Anisa A Cramer Jeff W JW Desai Prashant V PV Street Leslie J LJ Odingo Joshua J Masquelin Thierry T Chibale Kelly K Parish Tanya T
Bioorganic & medicinal chemistry letters 20180413 10
Despite increased research efforts to find new treatments for tuberculosis in recent decades, compounds with novel mechanisms of action are still required. We previously identified a series of novel aryl-oxadiazoles with anti-tubercular activity specific for bacteria using butyrate as a carbon source. We explored the structure activity relationship of this series. Structural modifications were performed in all domains to improve potency and physico-chemical properties. A number of compounds disp ...[more]