Ontology highlight
ABSTRACT:
SUBMITTER: Tahirovic YA
PROVIDER: S-EPMC5949813 | biostudies-other | 2018 May
REPOSITORIES: biostudies-other
ACS medicinal chemistry letters 20180409 5
A novel series of CXCR4 antagonists with piperidinyl and piperazinyl alkylamine side chains designed as butyl amine replacements are described. Several of these compounds showed similar activity to the parent compound TIQ-15 (<b>5</b>) in a SDF-1 induced calcium flux assay. Preliminary structure-activity relationship investigations led us to identify a series containing <i>N</i>-propyl piperazine side chain analogs exemplified by <b>16</b> with improved off-target effects as measured in a muscar ...[more]