Ontology highlight
ABSTRACT:
SUBMITTER: Fumagalli G
PROVIDER: S-EPMC5949839 | biostudies-other | 2018 May
REPOSITORIES: biostudies-other
Fumagalli Gaia G Giorgi Giulia G Vágvölgyi Máté M Colombo Eleonora E Christodoulou Michael S MS Collico Veronica V Prosperi Davide D Dosio Franco F Hunyadi Attila A Montopoli Monica M Hyeraci Mariafrancesca M Silvani Alessandra A Lesma Giordano G Via Lisa Dalla LD Passarella Daniele D
ACS medicinal chemistry letters 20180417 5
Heteronanoparticles (H-NPs) consisting of conjugates characterized by a squalene tail linked to doxorubicin and ecdysteroid derivatives are presented. Biological evaluation on A2780ADR cell line confirms not only the maintenance of the activity of the parental drug but also the ability to overcome cancer resistance. The <i>in vitro</i> cell uptake was demonstrated, and the involvement of an endosomal-mediated pathway was suggested. ...[more]