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HIV and Vertebral Fractures: a Systematic Review and Metanalysis.


ABSTRACT: The survival of HIV-infected patients has increased with the advent of antiretroviral therapy with the emergence of new comorbidities. Vertebral fracture is a manifestation of reduced bone strength and osteoporosis. This study aims to assess the frequency of spine fractures in HIV-positive men and women aged over 18 years. We performed a systematic review of randomized controlled trials, cohort studies, cross-sectional studies, and case-control studies. Studies that evaluated morphometric and/or clinical vertebral fracture were included. In total 488 studies were found, of which 53 had their full texts evaluated. A total of 85,411 HIV positive individuals were identified in 26 studies. The meta-analysis of the prevalence of vertebral fractures included 12 studies with 10,593 subjects. The prevalence was 11.1% [95% confidence interval (95% CI) 4.5%, 25.0%, I2 98.2% p?

SUBMITTER: Ilha TASH 

PROVIDER: S-EPMC5959850 | biostudies-other | 2018 May

REPOSITORIES: biostudies-other

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HIV and Vertebral Fractures: a Systematic Review and Metanalysis.

Ilha Thales A S H TASH   Comim Fabio V FV   Copes Rafaela M RM   Compston Juliet E JE   Premaor Melissa O MO  

Scientific reports 20180518 1


The survival of HIV-infected patients has increased with the advent of antiretroviral therapy with the emergence of new comorbidities. Vertebral fracture is a manifestation of reduced bone strength and osteoporosis. This study aims to assess the frequency of spine fractures in HIV-positive men and women aged over 18 years. We performed a systematic review of randomized controlled trials, cohort studies, cross-sectional studies, and case-control studies. Studies that evaluated morphometric and/or  ...[more]

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