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Stepwise control of host-guest interaction using a coordination polymer gel.

ABSTRACT: Precise control of host-guest interaction as seen in biological processes is difficult to achieve with artificial systems. Herein we have exploited the thermodynamic benefits of a system in equilibrium to achieve controlled stepwise release and capture of cyclodextrin (guest) using a coordination polymer (Mg-CP) as the host and temperature as the stimulus. Since temperature is not a precision stimulus for artificial host-guest interaction, the present system is a distinct prototype that manifests temperature-controlled natural host-guest interaction. The described coordination polymeric host system, when incorporated into a hydrogel matrix, provides a microenvironment that facilitates the stepwise release of ?-CD in response to temperature variation within a quasi-solid state. The work demonstrated here may pave the way towards thermally controlled delivery and monitoring of otherwise spectroscopically silent molecules such as cyclodextrins.

SUBMITTER: Mukhopadhyay RD

PROVIDER: S-EPMC5959896 | biostudies-other | 2018 May

REPOSITORIES: biostudies-other

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Stepwise control of host-guest interaction using a coordination polymer gel.

Mukhopadhyay Rahul Dev RD Das Gourab G Ajayaghosh Ayyappanpillai A

Nature communications 20180518 1

Precise control of host-guest interaction as seen in biological processes is difficult to achieve with artificial systems. Herein we have exploited the thermodynamic benefits of a system in equilibrium to achieve controlled stepwise release and capture of cyclodextrin (guest) using a coordination polymer (Mg-CP) as the host and temperature as the stimulus. Since temperature is not a precision stimulus for artificial host-guest interaction, the present system is a distinct prototype that manifest ...[more]

PMID: 29777098

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