Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC5963864 | biostudies-other | 2018 Apr
REPOSITORIES: biostudies-other
Development (Cambridge, England) 20180404 7
During vertebrate gastrulation, canonical Wnt signaling induces the formation of neural plate border (NPB). Wnt is also thought to be required for the subsequent specification of neural crest (NC) lineage at the NPB, but the direct evidence is lacking. We found previously that the disintegrin metalloproteinase ADAM13 is required for Wnt activation and NC induction in <i>Xenopus</i> Here, we report that knockdown of ADAM13 or its close paralog ADAM19 severely downregulates Wnt activity at the NPB ...[more]