Ontology highlight
ABSTRACT:
SUBMITTER: Lu Y
PROVIDER: S-EPMC5974273 | biostudies-other | 2018 May
REPOSITORIES: biostudies-other
Lu Yuan Y Fujioka Hisashi H Joshi Dinesh D Li Qiaoyuan Q Sangwung Panjamaporn P Hsieh Paishiun P Zhu Jiyun J Torio Jose J Sweet David D Wang Lan L Chiu Shing Yan SY Croniger Colleen C Liao Xudong X Jain Mukesh K MK
Scientific reports 20180529 1
Brown adipose tissue (BAT) is a specialized thermogenic organ in mammals. The ability of BAT mitochondria to generate heat in response to cold-challenge to maintain core body temperature is essential for organismal survival. While cold activated BAT mitochondrial biogenesis is recognized as critical for thermogenic adaptation, the contribution of mitochondrial quality control to this process remains unclear. Here, we show mitophagy is required for brown adipocyte mitochondrial homeostasis during ...[more]