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Drug Delivery Strategies for Antivirals against Hepatitis B Virus.

ABSTRACT: Chronic hepatitis B virus (HBV) infection poses a significant health challenge due to associated morbidity and mortality from cirrhosis and hepatocellular cancer that eventually results in the breakdown of liver functionality. Nanotechnology has the potential to play a pivotal role in reducing viral load levels and drug-resistant HBV through drug targeting, thus reducing the rate of evolution of the disease. Apart from tissue targeting, intracellular delivery of a wide range of drugs is necessary to exert a therapeutic action in the affected organelles. This review encompasses the strategies and techniques that have been utilized to target the HBV-infected nuclei in liver hepatocytes, with a significant look at the new insights and most recent advances in drug carriers and their role in anti-HBV therapy.

SUBMITTER: Singh L

PROVIDER: S-EPMC5977260 | biostudies-other | 2018 May

REPOSITORIES: biostudies-other

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Drug Delivery Strategies for Antivirals against Hepatitis B Virus.

Singh Latavia L Indermun Sunaina S Govender Mershen M Kumar Pradeep P du Toit Lisa C LC Choonara Yahya E YE Pillay Viness V

Viruses 20180517 5

Chronic hepatitis B virus (HBV) infection poses a significant health challenge due to associated morbidity and mortality from cirrhosis and hepatocellular cancer that eventually results in the breakdown of liver functionality. Nanotechnology has the potential to play a pivotal role in reducing viral load levels and drug-resistant HBV through drug targeting, thus reducing the rate of evolution of the disease. Apart from tissue targeting, intracellular delivery of a wide range of drugs is necessar ...[more]

PMID: 29772748

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