Ontology highlight
ABSTRACT:
SUBMITTER: Tsai SW
PROVIDER: S-EPMC5983692 | biostudies-other | 2018 May
REPOSITORIES: biostudies-other
Tsai Sen-Wei SW Hsieh Ming-Chia MC Li Shiming S Lin Shih-Chao SC Wang Shun-Ping SP Lehman Caitlin W CW Lien Christopher Z CZ Lin Chi-Chien CC
International journal of molecular sciences 20180503 5
Previous studies have shown that the natural diterpene compound, sclareol, potentially inhibits inflammation, but it has not yet been determined whether sclareol can alleviate inflammation associated with rheumatoid arthritis (RA). Here, we utilized human synovial cell line, SW982, and an experimental murine model of rheumatoid arthritis, collagen-induced arthritis (CIA), to evaluate the therapeutic effects of sclareol in RA. Arthritic DBA/1J mice were dosed with 5 and 10 mg/kg sclareol intraper ...[more]