Loss of periostin ameliorates adipose tissue inflammation and fibrosis in vivo.
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ABSTRACT:
SUBMITTER: Nakazeki F
PROVIDER: S-EPMC5986813 | biostudies-other | 2018 Jun
REPOSITORIES: biostudies-other
Publications
Loss of periostin ameliorates adipose tissue inflammation and fibrosis in vivo.
Nakazeki Fumiko F Nishiga Masataka M Horie Takahiro T Nishi Hitoo H Nakashima Yasuhiro Y Baba Osamu O Kuwabara Yasuhide Y Nishino Tomohiro T Nakao Tetsushi T Ide Yuya Y Koyama Satoshi S Kimura Masahiro M Tsuji Shuhei S Sowa Naoya N Yoshida Shigeo S Conway Simon J SJ Yanagita Motoko M Kimura Takeshi T Ono Koh K
Scientific reports 20180604 1
Recent evidence suggests that the accumulation of macrophages as a result of obesity-induced adipose tissue hypoxia is crucial for the regulation of tissue fibrosis, but the molecular mechanisms underlying adipose tissue fibrosis are still unknown. In this study, we revealed that periostin (Postn) is produced at extraordinary levels by adipose tissue after feeding with a high-fat diet (HFD). Postn was secreted at least from macrophages in visceral adipose tissue during the development of obesity ...[more]
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