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Transient immediate postoperative homotopic functional disconnectivity in low-grade glioma patients.


ABSTRACT: The aim of this longitudinal study is to evaluate large-scale perioperative resting state networks reorganization in patients with diffuse low-grade gliomas following awake surgery.Eighty-two patients with diffuse low-grade gliomas were prospectively enrolled and underwent awake surgical resection. Resting-state functional images were acquired at three time points: preoperative (MRI-1), immediate postoperative (MRI-2) and three months after surgery (MRI-3). We simultaneously performed perfusion-weighted imaging.Comparing functional connectivity between MRI-1 and MRI-2, we observed a statistically significant functional homotopy decrease in cortical and subcortical supratentorial structures (P?

SUBMITTER: Coget A 

PROVIDER: S-EPMC5987867 | biostudies-other | 2018

REPOSITORIES: biostudies-other

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Transient immediate postoperative homotopic functional disconnectivity in low-grade glioma patients.

Coget Arthur A   Deverdun Jérémy J   Bonafé Alain A   van Dokkum Liesjet L   Duffau Hugues H   Molino François F   Le Bars Emmanuelle E   de Champfleur Nicolas Menjot NM  

NeuroImage. Clinical 20180226


<h4>Background and purpose</h4>The aim of this longitudinal study is to evaluate large-scale perioperative resting state networks reorganization in patients with diffuse low-grade gliomas following awake surgery.<h4>Materials and methods</h4>Eighty-two patients with diffuse low-grade gliomas were prospectively enrolled and underwent awake surgical resection. Resting-state functional images were acquired at three time points: preoperative (MRI-1), immediate postoperative (MRI-2) and three months  ...[more]

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