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Fasting and postprandial soluble epoxide hydrolase-associated eicosanoids of remitted patients with eating disorder.

ABSTRACT: Food aversion and food avoidance are significant challenges to overcome for patients with eating disorder such as anorexia nervosa. The epoxide hydrolase 2 gene (EPXH2) has been uncovered as a novel anorexia nervosa risk gene. We have also discovered EPHX2-associated eicosanoids derived from polyunsaturated fatty acids to be aberrant in patients with anorexia nervosa, suggesting that genetically moderated lipid metabolism may be an underlying factor in AN pathogenesis. The data presented in this article are related to the research article entitled "Personalized polyunsaturated fatty acids as a potential adjunctive treatment for anorexia nervosa" [1]. In this data article, we provide both fasting and non-fasting (postprandial) concentration of eicosanoids in remitted patients with eating disorder and healthy controls. The data provides information on quantitative bioactive lipid mediators in fasting as well as non-fasting states, allowing inference of lipid metabolism associated with food consumption. The data set is made available to enable critical or extended analyzes.

SUBMITTER: Yang J 

PROVIDER: S-EPMC5988286 | biostudies-other | 2018 Apr

REPOSITORIES: biostudies-other

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Fasting and postprandial soluble epoxide hydrolase-associated eicosanoids of remitted patients with eating disorder.

Yang Jun J   Shih Pei-An Betty PB  

Data in brief 20180131

Food aversion and food avoidance are significant challenges to overcome for patients with eating disorder such as anorexia nervosa. The epoxide hydrolase 2 gene (<i>EPXH2</i>) has been uncovered as a novel anorexia nervosa risk gene. We have also discovered <i>EPHX2</i>-associated eicosanoids derived from polyunsaturated fatty acids to be aberrant in patients with anorexia nervosa, suggesting that genetically moderated lipid metabolism may be an underlying factor in AN pathogenesis. The data pre  ...[more]