Data on alcohol consumption and coronary artery calcification among asymptomatic middle-aged men for the ERA-JUMP study.
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ABSTRACT:
SUBMITTER: Mahajan H
PROVIDER: S-EPMC5988411 | biostudies-other | 2018 Apr
REPOSITORIES: biostudies-other
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Data on alcohol consumption and coronary artery calcification among asymptomatic middle-aged men for the ERA-JUMP study.
Mahajan Hemant H Choo Jina J Masaki Kamal K Fujiyoshi Akira A Guo Jingchuan J Hisamatsu Takashi T Evans Rhobert R Shangguan Siyi S Willcox Bradley B Okamura Tomonori T Vishnu Abhishek A Barinas-Mitchell Emma E Ahuja Vasudha V Miura Katsuyuki K Kuller Lewis L Shin Chol C Ueshima Hirotsugu H Sekikawa Akira A
Data in brief 20180216
Data presented in this article are supplementary data to our primary article 'Association of Alcohol Consumption and Aortic Calcification in Healthy Men Aged 40-49 Years for the ERA JUMP Study' [1]. In this article, we have presented supplementary tables showing the independent association of alcohol consumption with coronary artery calcification using Tobit conditional regression and ordinal logistic regression. ...[more]
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Project description:BackgroundEquol, an isoflavone (ISF)-derived metabolite by the gut microbiome in certain individuals termed as equol-producers, might be the key anti-atherogenic component of ISFs. Our objective was to determine the association between equol-producing status and aortic atherosclerosis assessed as aortic calcification (AC).MethodsThis population-based study of 302 Japanese men aged 40-49, free of cardiovascular disease, examined serum levels of equol and ISFs, AC in the entire aorta by electron-beam computed tomography with Agatston method, and cardiovascular risk factors. We defined equol-producers as individuals with serum levels of equol ≥20 nM and prevalent AC as an AC score ≥ 10. We analyzed the association between equol-producing status and AC using Tobit and logistic regressions. We performed age-stratified analyses since age was a significant effect-modifier.ResultsThe 70th to 90th percentile AC scores were 4 to 243 in equol-producers and 15 to 444 in non-producers, respectively. Overall, equol-producers (41% of the sample) had lower AC scores (-209, [95% confidence interval (CI): -455, 36]) and odds of AC (odds ratio (OR): 0.7 [95% CI: 0.4, 1.3]), although not statistically significant, compared to non-producers after controlling for cardiovascular risk factors. Among men aged 46-49, equol-producers had significantly lower AC scores (-428 [95% CI: -827, -29]). Furthermore, there were null associations between serum levels of ISFs and both AC score and the odds of AC.ConclusionIn middle-aged Japanese men, equol-producers had a non-significantly lower burden of aortic atherosclerosis than non-producers whereas ISFs had a null association. Studies with larger sample sizes in both sexes are warranted.
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