Ontology highlight
ABSTRACT:
SUBMITTER: Jiskoot LC
PROVIDER: S-EPMC5990575 | biostudies-other | 2018 Jun
REPOSITORIES: biostudies-other
Jiskoot Lize C LC Panman Jessica L JL van Asseldonk Lauren L Franzen Sanne S Meeter Lieke H H LHH Donker Kaat Laura L van der Ende Emma L EL Dopper Elise G P EGP Timman Reinier R van Minkelen Rick R van Swieten John C JC van den Berg Esther E Papma Janne M JM
Journal of neurology 20180407 6
<h4>Introduction</h4>We performed 4-year follow-up neuropsychological assessment to investigate cognitive decline and the prognostic abilities from presymptomatic to symptomatic familial frontotemporal dementia (FTD).<h4>Methods</h4>Presymptomatic MAPT (n = 15) and GRN mutation carriers (n = 31), and healthy controls (n = 39) underwent neuropsychological assessment every 2 years. Eight mutation carriers (5 MAPT, 3 GRN) became symptomatic. We investigated cognitive decline with multilevel regress ...[more]