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Macular Choroidal Thickening in Keratoconus Patients: Swept-Source Optical Coherence Tomography Study.


ABSTRACT: To determine the choroidal thickness (CT) profile in keratoconus (KC) patients using swept-source optical coherence tomography (SS-OCT).This was a prospective, cross-sectional study. One hundred two eyes of 52 KC patients were studied using Pentacam and SS-OCT. The macular CT profile was created by manually measuring the distance between the retinal pigment epithelium and the choroid-sclera junction on horizontal b-scans at nine different macular locations. The results were compared to 93 eyes of 93 healthy controls.Mean age of the KC group was 34.9 ± 13.5 years and mean axial length (AL) was 24.1 ± 1.3 mm. Mean topographic KC classification (TKC) was 2.0; 39 eyes were classified as early KC (TKC <1-2), 34 eyes as moderate (TKC 2, 2-3), and 29 as advanced (TKC 3+). Mean subfoveal CT was 383.2 ?m in KC patients and 280.5 ?m in control group (P < 0.001). CT in KC patients was statistically thicker in all measure locations (P < 0.001). CT in KC eyes decreased with age, approaching control group at >45 years old, losing statistical significance (P = 0.37).CT in KC patients is statistically thicker than in healthy population. After age 45, CT decreases approaching control group values.This study describes changes in the CT profile of KC patients, a disease that was considered purely corneal. These choroidal changes argue that KC is a disease that likely involves several ocular structures other than the cornea, and could open new research lines related to the pathophysiology of KC.

SUBMITTER: Gutierrez-Bonet R 

PROVIDER: S-EPMC5991807 | biostudies-other | 2018 May

REPOSITORIES: biostudies-other

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Macular Choroidal Thickening in Keratoconus Patients: Swept-Source Optical Coherence Tomography Study.

Gutierrez-Bonet Rosa R   Ruiz-Medrano Jorge J   Peña-Garcia Pablo P   Catanese Muriel M   Sadeghi Yalda Y   Hashemi Katayoon K   Gabison Eric E   Ruiz-Moreno José M JM  

Translational vision science & technology 20180501 3


<h4>Purpose</h4>To determine the choroidal thickness (CT) profile in keratoconus (KC) patients using swept-source optical coherence tomography (SS-OCT).<h4>Methods</h4>This was a prospective, cross-sectional study. One hundred two eyes of 52 KC patients were studied using Pentacam and SS-OCT. The macular CT profile was created by manually measuring the distance between the retinal pigment epithelium and the choroid-sclera junction on horizontal b-scans at nine different macular locations. The re  ...[more]

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