Ontology highlight
ABSTRACT:
SUBMITTER: Chi B
PROVIDER: S-EPMC5993797 | biostudies-other | 2018 Jun
REPOSITORIES: biostudies-other
Chi Binkai B O'Connell Jeremy D JD Yamazaki Tomohiro T Gangopadhyay Jaya J Gygi Steven P SP Reed Robin R
Scientific reports 20180608 1
Mutations in multiple RNA/DNA binding proteins cause Amyotrophic Lateral Sclerosis (ALS). Included among these are the three members of the FET family (FUS, EWSR1 and TAF15) and the structurally similar MATR3. Here, we characterized the interactomes of these four proteins, revealing that they largely have unique interactors, but share in common an association with U1 snRNP. The latter observation led us to analyze the interactome of the U1 snRNP machinery. Surprisingly, this analysis revealed th ...[more]