Ontology highlight
ABSTRACT:
SUBMITTER: Auffret M
PROVIDER: S-EPMC5995787 | biostudies-other | 2018 Jun
REPOSITORIES: biostudies-other
Drugs in R&D 20180601 2
Apomorphine is now recognized as the oldest antiparkinsonian drug on the market. Though still underused, it is increasingly prescribed in Europe for patients with advanced Parkinson's disease (PD) with motor fluctuations. However, its history is far from being limited to movement disorders. This paper traces the history of apomorphine, from its earliest empirical use, to its synthesis, pharmacological development, and numerous indications in human and veterinary medicine, in light of its most re ...[more]