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Optical control of neuronal firing via photoinduced electron transfer in donor-acceptor conjugates.

ABSTRACT: A series of porphyrin-fullerene linked molecules has been synthesized to evaluate the effects of substituents and molecular structures on their charge-separation yield and the lifetime of a final charge-separated state in various hydrophilic environments. The selected high-performance molecule effectively achieved depolarization in a plasma cell membrane by visible light as well as two-photon excitation using a near-infrared light laser. Moreover, it was revealed that the depolarization can trigger neuronal firing in rat hippocampal neurons, demonstrating the potential and versatility for controlling cell functions using light.

SUBMITTER: Takano Y

PROVIDER: S-EPMC6006863 | biostudies-other | 2016 May

REPOSITORIES: biostudies-other

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Optical control of neuronal firing <i>via</i> photoinduced electron transfer in donor-acceptor conjugates.

Takano Yuta Y Numata Tomohiro T Fujishima Kazuto K Miyake Kazuaki K Nakao Kazuya K Grove Wesley David WD Inoue Ryuji R Kengaku Mineko M Sakaki Shigeyoshi S Mori Yasuo Y Murakami Tatsuya T Imahori Hiroshi H

Chemical science 20160217 5

A series of porphyrin-fullerene linked molecules has been synthesized to evaluate the effects of substituents and molecular structures on their charge-separation yield and the lifetime of a final charge-separated state in various hydrophilic environments. The selected high-performance molecule effectively achieved depolarization in a plasma cell membrane by visible light as well as two-photon excitation using a near-infrared light laser. Moreover, it was revealed that the depolarization can trig ...[more]

PMID: 29997826

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