Associations of serum calcium levels and dietary calcium intake with incident type 2 diabetes over 10 years: the Korean Genome and Epidemiology Study (KoGES).

ABSTRACT: Previous evidence regarding the associations between serum calcium concentrations, dietary calcium intake, and type 2 diabetes (T2D) is limited. We investigated the longitudinal associations of serum calcium levels and dietary calcium intake with T2D development.This study used data from the Ansung-Ansan cohort, a community-based, prospective cohort that was followed up for 10 years. Cox regression models adjusted for potential confounders were used to evaluate the associations of serum calcium levels (mean, 9.41 mg/dL) and dietary calcium intake (median, 389.59 mg/day) with T2D incidence. Association between dietary calcium intake and serum calcium levels was assessed using linear regression models.Albumin-adjusted serum calcium levels were not associated with T2D risk (hazard ratio [HR]?=?1.07, 95% confidence interval [CI] 0.96, 1.19, p-value?=?0.2333). A one-unit increase in log-transformed, energy-adjusted dietary calcium intake was associated with a decreased risk of T2D (HR?=?0.88, 95% CI 0.77, 1.00, p-value?=?0.0460) and lower albumin-adjusted serum calcium levels (??=?-?0.04, 95% CI -?0.07, -?0.02, p-value?=?0.0014). The associations did not differ according to sex (all p-values for interaction?>?0.10).Serum calcium levels were not associated with T2D risk, while higher dietary calcium intake was associated with a decreased risk of T2D development. These results have public health implications for predicting and preventing T2D development, as well as providing guidelines for diet and calcium supplementation.

SUBMITTER: Kim KN 

PROVIDER: S-EPMC6006916 | biostudies-other | 2018

REPOSITORIES: biostudies-other