Ontology highlight
ABSTRACT:
SUBMITTER: Marchena M
PROVIDER: S-EPMC6009897 | biostudies-other | 2017 Dec
REPOSITORIES: biostudies-other
Marchena Miguel M Villarejo-Zori Beatriz B Zaldivar-Diez Josefa J Palomo Valle V Gil Carmen C Hernández-Sánchez Catalina C Martínez Ana A de la Rosa Enrique J EJ
Journal of enzyme inhibition and medicinal chemistry 20171201 1
Retinitis pigmentosa (RP) is an inherited retinal dystrophy that courses with progressive degeneration of retinal tissue and loss of vision. Currently, RP is an unpreventable, incurable condition. We propose glycogen synthase kinase 3 (GSK-3) inhibitors as potential leads for retinal cell neuroprotection, since the retina is also a part of the central nervous system and GSK-3 inhibitors are potent neuroprotectant agents. Using a chemical genetic approach, diverse small molecules with different p ...[more]