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Amniotic membrane extract and eye drops: a review of literature and clinical application.


ABSTRACT: The amniotic membrane (AM) has a long history of use in the treatment of various diseases of the ocular surface. It contains pluripotent cells, highly organized collagen, anti-fibrotic and anti-inflammatory cytokines, immune-modulators, growth factors, and matrix proteins. It is used to promote corneal healing in severely damaged eyes. Recently, AM extract and AM extract eye drops have been successfully used in clinical applications, including dry eye and chemical burns. We provide an overview on the recent progress in the preparation, mechanisms of action, and use of AM extract/AM extract eye drops for corneal and external eye diseases.

SUBMITTER: Murri MS 

PROVIDER: S-EPMC6012548 | biostudies-other | 2018

REPOSITORIES: biostudies-other

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Amniotic membrane extract and eye drops: a review of literature and clinical application.

Murri Michael S MS   Moshirfar Majid M   Birdsong Orry C OC   Ronquillo Yasmyne C YC   Ding Yanning Y   Hoopes Phillip C PC  

Clinical ophthalmology (Auckland, N.Z.) 20180618


The amniotic membrane (AM) has a long history of use in the treatment of various diseases of the ocular surface. It contains pluripotent cells, highly organized collagen, anti-fibrotic and anti-inflammatory cytokines, immune-modulators, growth factors, and matrix proteins. It is used to promote corneal healing in severely damaged eyes. Recently, AM extract and AM extract eye drops have been successfully used in clinical applications, including dry eye and chemical burns. We provide an overview o  ...[more]

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2017-09-26 | GSE103413 | GEO