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Amyloid Biomarkers in Conformational Diseases at Face Value: A Systematic Review.


ABSTRACT: Conformational diseases represent a new aspect of proteomic medicine where diagnostic and therapeutic paradigms are evolving. In this context, the early biomarkers for target cell failure (neurons, ?-cells, etc.) represent a challenge to translational medicine and play a multidimensional role as biomarkers and potential therapeutic targets. This systematic review, which follows the PICO and Prisma methods, analyses this new-fangled multidimensionality, its strengths and limitations, and presents the future possibilities it opens up. The nuclear diagnosis methods are immunoassays: ELISA, immunodot, western blot, etc., while the therapeutic approach is focused on pharmaco- and molecular chaperones.

SUBMITTER: Avila-Vazquez MF 

PROVIDER: S-EPMC6017595 | biostudies-other | 2017 Dec

REPOSITORIES: biostudies-other

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Amyloid Biomarkers in Conformational Diseases at Face Value: A Systematic Review.

Avila-Vazquez Maria Fernanda MF   Altamirano-Bustamante Nelly F NF   Altamirano-Bustamante Myriam M MM  

Molecules (Basel, Switzerland) 20171229 1


Conformational diseases represent a new aspect of proteomic medicine where diagnostic and therapeutic paradigms are evolving. In this context, the early biomarkers for target cell failure (neurons, β-cells, etc.) represent a challenge to translational medicine and play a multidimensional role as biomarkers and potential therapeutic targets. This systematic review, which follows the PICO and Prisma methods, analyses this new-fangled multidimensionality, its strengths and limitations, and presents  ...[more]

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