Dataset Information
Nickel-catalyzed cyclization of alkyne-nitriles with organoboronic acids involving anti-carbometalation of alkynes.
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ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC6021782 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
Publications
Nickel-catalyzed cyclization of alkyne-nitriles with organoboronic acids involving <i>anti</i>-carbometalation of alkynes.
Chemical science 20160519 9
A nickel-catalyzed regioselective addition/cyclization of <i>o</i>-(cyano)phenyl propargyl ethers with arylboronic acids has been developed, which provides an efficient protocol for the synthesis of highly functionalized 1-naphthylamines with wide structural diversity. The reaction is characterized by a regioselective and <i>anti</i>-addition of the arylboronic acids to the alkyne and subsequent facile nucleophilic addition of the resulting alkenylmetal to the tethered cyano group. Mechanistic s ...[more]