Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC6021782 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
Chemical science 20160519 9
A nickel-catalyzed regioselective addition/cyclization of <i>o</i>-(cyano)phenyl propargyl ethers with arylboronic acids has been developed, which provides an efficient protocol for the synthesis of highly functionalized 1-naphthylamines with wide structural diversity. The reaction is characterized by a regioselective and <i>anti</i>-addition of the arylboronic acids to the alkyne and subsequent facile nucleophilic addition of the resulting alkenylmetal to the tethered cyano group. Mechanistic s ...[more]