Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC6030162 | biostudies-other | 2018 Jul
REPOSITORIES: biostudies-other
Li Xiaoju X Gao Yuan Y Li Jialin J Zhang Kuo K Han Jun J Li Weina W Hao Qiang Q Zhang Wangqian W Wang Shuning S Zeng Cheng C Zhang Wei W Zhang Yingqi Y Li Meng M Zhang Cun C
Cell death & disease 20180703 7
Forkhead box P3 (FOXP3), an X-linked tumor suppressor gene, plays an important role in breast cancer. However, the biological functions of FOXP3 in breast cancer angiogenesis remain unclear. Here we found that the clinical expression of nuclear FOXP3 was inversely correlated with breast cancer angiogenesis. Moreover, the animal study demonstrated that FOXP3 significantly reduced the microvascular density of MDA-MB-231 tumors transplanted in mice. The cytological experiments showed that the super ...[more]