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Chronotype and social jetlag influence human circadian clock gene expression.


ABSTRACT: We examined the relationships between chronotype or social jetlag and clock gene expression. Twenty-four young men [Chronotype: morningness, n?=?8; intermediate, n?=?8, eveningness, n?=?8], aged 27?±?2 years old (mean?±?SE), completed two trials in a randomized order: (1) a Friday trial and (2) a Monday trial. In both trials, hair follicle cells were collected to evaluate the expression of clock genes over a 24-hour period at 4-hour intervals. There was a significant main effect of time on the expression of NR1D1, NR1D2, and PER3 (P?

SUBMITTER: Takahashi M 

PROVIDER: S-EPMC6033857 | biostudies-other | 2018 Jul

REPOSITORIES: biostudies-other

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Chronotype and social jetlag influence human circadian clock gene expression.

Takahashi Masaki M   Tahara Yu Y   Tsubosaka Miku M   Fukazawa Mayuko M   Ozaki Mamiho M   Iwakami Tamao T   Nakaoka Takashi T   Shibata Shigenobu S  

Scientific reports 20180705 1


We examined the relationships between chronotype or social jetlag and clock gene expression. Twenty-four young men [Chronotype: morningness, n = 8; intermediate, n = 8, eveningness, n = 8], aged 27 ± 2 years old (mean ± SE), completed two trials in a randomized order: (1) a Friday trial and (2) a Monday trial. In both trials, hair follicle cells were collected to evaluate the expression of clock genes over a 24-hour period at 4-hour intervals. There was a significant main effect of time on the e  ...[more]

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