Dataset Information

Reconstructing the sediment concentration of a giant submarine gravity flow.

ABSTRACT: Submarine gravity flows are responsible for the largest sediment accumulations on the planet, but are notoriously difficult to measure in action. Giant flows transport 100s of km3 of sediment with run-out distances over 2000?km. Sediment concentration is a first order control on flow dynamics and deposit character. It has never been measured directly nor convincingly estimated in large submarine flows. Here we reconstruct the sediment concentration of a historic giant submarine flow, the 1929 "Grand Banks" event, using two independent approaches, each validated by estimates of flow speed from cable breaks. The calculated average bulk sediment concentration of the flow was 2.7-5.4% by volume. This is orders of magnitude higher than directly-measured smaller-volume flows in river deltas and submarine canyons. The new concentration estimate provides a test case for scaled experiments and numerical simulations, and a major step towards a quantitative understanding of these prodigious flows.

SUBMITTER: Stevenson CJ

PROVIDER: S-EPMC6033887 | biostudies-other | 2018 Jul

REPOSITORIES: biostudies-other

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Reconstructing the sediment concentration of a giant submarine gravity flow.

Stevenson Christopher John CJ Feldens Peter P Georgiopoulou Aggeliki A Schӧnke Mischa M Krastel Sebastian S Piper David J W DJW Lindhorst Katja K Mosher David D

Nature communications 20180705 1

Submarine gravity flows are responsible for the largest sediment accumulations on the planet, but are notoriously difficult to measure in action. Giant flows transport 100s of km<sup>3</sup> of sediment with run-out distances over 2000 km. Sediment concentration is a first order control on flow dynamics and deposit character. It has never been measured directly nor convincingly estimated in large submarine flows. Here we reconstruct the sediment concentration of a historic giant submarine flow, ...[more]

PMID: 29976991

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Project description:Microphysiological systems, also known as body-on-a-chips, are promising "human surrogates" that may be used to evaluate potential human response to drugs in preclinical drug development. Various microfluidics-based platforms have been proposed to interconnect different organ models and provide perfusion in mimicking the blood circulation. We have previously developed a pumpless platform that combines gravity-driven fluid flow and a rocking motion to create reciprocating flow between reservoirs for recirculation. Such platform allows design of self-contained and highly integrated systems that are relatively easy and cost-effective to construct and maintain. To integrate vasculature and other shear stress-sensitive tissues (e.g. lung and kidney) into pumpless body-on-a-chips, we propose "UniChip" fluid network design, which transforms reciprocating flow input into unidirectional perfusion in the channel(s) of interest by utilizing supporting channels and passive valves. The design enables unidirectional organ perfusion with recirculation on the pumpless platform and provides an effective backflow-proof mechanism. To demonstrate principles of UniChip design, we created a demonstration chip with a single straight channel as a simple example of the organ perfusion network. A BiChip providing bidirectional perfusion was used for comparison. Computational and experimental fluid dynamic characterization of the UniChip confirmed continuous unidirectional flow in the perfusion channel and the backflow-proof mechanism. Vascular endothelial cells cultured on UniChips for 5 d showed changes matching cell responses to unidirectional laminar flows. Those include cell elongation and alignment to the flow direction, continuous network of VE-cadherin at cell borders, realignment of F-actin and suppressed cell proliferation. Cells on BiChips manifested distinct responses that are close to responses to oscillatory flows, where cells remain a polygonal shape with intermittent VE-cadherin networks and few F-actin realignment. These results demonstrate that microfluidic devices of UniChip design provide recirculating unidirectional perfusion suitable for long-term culture of shear stress-sensitive tissues. This is the first time a gravity-drive flow system has achieved continuous unidirectional perfusion with recirculation. The inherent backflow-proof mechanism allows hassle-free long-term operation of body-on-a-chips. Overall, our UniChip design provides a reliable and cost-effective solution for the integration of vasculature and other shear stress-sensitive tissues into pumpless recirculating body-on-a-chips, which can expedite the development and widespread application of moderately high-throughput, high-content microphysiological systems.

Dataset Information

Reconstructing the sediment concentration of a giant submarine gravity flow.

Publications

Reconstructing the sediment concentration of a giant submarine gravity flow.

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