Ontology highlight
ABSTRACT:
SUBMITTER: Mender I
PROVIDER: S-EPMC6037876 | biostudies-other | 2018 Jul
REPOSITORIES: biostudies-other
Neoplasia (New York, N.Y.) 20180706 8
Standard and targeted cancer therapies for late-stage cancer patients almost universally fail due to tumor heterogeneity/plasticity and intrinsic or acquired drug resistance. We used the telomerase substrate nucleoside precursor, 6-thio-2'-deoxyguanosine (6-thio-dG), to target telomerase-expressing non-small cell lung cancer cells resistant to EGFR-inhibitors and commonly used chemotherapy combinations. Colony formation assays, human xenografts as well as syngeneic and genetically engineered imm ...[more]