Dissecting how modular polyketide synthase ketoreductases interact with acyl carrier protein-attached substrates.

ABSTRACT: Interaction studies using fragments excised from the modular mycolactone polyketide synthase show that ketoreductase domains possess a generic binding site for acyl carrier protein domains and provide evidence that the pendant 5'-phosphopantetheine prosthetic group plays a key role in delivering acyl substrates to the active site in the correct orientation.

SUBMITTER: Moretto L 

PROVIDER: S-EPMC6038798 | biostudies-other | 2017 Oct

REPOSITORIES: biostudies-other