Ontology highlight
ABSTRACT:
SUBMITTER: Yun SP
PROVIDER: S-EPMC6039259 | biostudies-other | 2018 Jul
REPOSITORIES: biostudies-other
Yun Seung Pil SP Kam Tae-In TI Panicker Nikhil N Kim SangMin S Oh Yumin Y Park Jong-Sung JS Kwon Seung-Hwan SH Kwon Seung-Hwan SH Park Yong Joo YJ Karuppagounder Senthilkumar S SS Park Hyejin H Kim Sangjune S Oh Nayeon N Kim Nayoung Alice NA Lee Saebom S Brahmachari Saurav S Mao Xiaobo X Lee Jun Hee JH Kumar Manoj M An Daniel D Kang Sung-Ung SU Lee Yunjong Y Lee Kang Choon KC Na Dong Hee DH Kim Donghoon D Lee Sang Hun SH Roschke Viktor V VV Liddelow Shane A SA Mari Zoltan Z Barres Ben A BA Dawson Valina L VL Lee Seulki S Dawson Ted M TM Ko Han Seok HS
Nature medicine 20180611 7
Activation of microglia by classical inflammatory mediators can convert astrocytes into a neurotoxic A1 phenotype in a variety of neurological diseases<sup>1,2</sup>. Development of agents that could inhibit the formation of A1 reactive astrocytes could be used to treat these diseases for which there are no disease-modifying therapies. Glucagon-like peptide-1 receptor (GLP1R) agonists have been indicated as potential neuroprotective agents for neurologic disorders such as Alzheimer's disease and ...[more]