Ontology highlight
ABSTRACT:
SUBMITTER: Kulesa A
PROVIDER: S-EPMC6042083 | biostudies-other | 2018 Jun
REPOSITORIES: biostudies-other
Kulesa Anthony A Kehe Jared J Hurtado Juan E JE Tawde Prianca P Blainey Paul C PC
Proceedings of the National Academy of Sciences of the United States of America 20180613 26
Combinatorial drug treatment strategies perturb biological networks synergistically to achieve therapeutic effects and represent major opportunities to develop advanced treatments across a variety of human disease areas. However, the discovery of new combinatorial treatments is challenged by the sheer scale of combinatorial chemical space. Here, we report a high-throughput system for nanoliter-scale phenotypic screening that formulates a chemical library in nanoliter droplet emulsions and automa ...[more]