Ontology highlight
ABSTRACT:
SUBMITTER: Lujan AL
PROVIDER: S-EPMC6042088 | biostudies-other | 2018 Jun
REPOSITORIES: biostudies-other
Lujan Agustin L AL Croci Diego O DO Gambarte Tudela Julián A JA Losinno Antonella D AD Cagnoni Alejandro J AJ Mariño Karina V KV Damiani María T MT Rabinovich Gabriel A GA
Proceedings of the National Academy of Sciences of the United States of America 20180611 26
<i>Chlamydia trachomatis</i> (<i>Ct</i>) constitutes the most prevalent sexually transmitted bacterium worldwide. Chlamydial infections can lead to severe clinical sequelae including pelvic inflammatory disease, ectopic pregnancy, and tubal infertility. As an obligate intracellular pathogen, <i>Ct</i> has evolved multiple strategies to promote adhesion and invasion of host cells, including those involving both bacterial and host glycans. Here, we show that galectin-1 (Gal1), an endogenous lectin ...[more]