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Comparison of Image-Guided Intensity-Modulated Radiotherapy and Low-dose Rate Brachytherapy with or without External Beam Radiotherapy in Patients with Localized Prostate Cancer.


ABSTRACT: To compare the outcome of low-dose rate brachytherapy (LDR-BT) and image-guided intensity-modulated radiotherapy (IG-IMRT) for localized prostate cancer, we examined 488 LDR-BT and 269 IG-IMRT patients. IG-IMRT treated older and advanced disease with more hormonal therapy than LDR-BT, which excluded T3b-T4 tumor and initial PSA?>?50?ng/ml. The actuarial five-year biochemical failure-free survival rate was 88.7% and 96.7% (p?=?0.0003) in IG-IMRT and LDR-BT, respectively; it was 88.2% (85.1% for IG-IMRT and 94.9% for LDR-BT, p?=?0.0578) for the high-risk group, 95.2% (91.6% and 97.0%, p?=?0.3361) for the intermediate IG-IMRT and 96.8% (95.7% and 97%, p?=?0.8625) for the low-risk group. Inverse probability of treatment weighting (IPTW) involving propensity scores was used to reduce background selection bias. IPTW showed a statistically significant difference between LDR-BT and IG-IMRT in high risk (p?=?0.0009) and high risk excluding T3-4/initial PSA?>?50?ng/ml group (p?=?0.0073). IG-IMRT showed more gastrointestinal toxicity (p?=?0.0023) and less genitourinary toxicity (p?

SUBMITTER: Tsubokura T 

PROVIDER: S-EPMC6043516 | biostudies-other | 2018 Jul

REPOSITORIES: biostudies-other

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Comparison of Image-Guided Intensity-Modulated Radiotherapy and Low-dose Rate Brachytherapy with or without External Beam Radiotherapy in Patients with Localized Prostate Cancer.

Tsubokura Takuji T   Yamazaki Hideya H   Masui Koji K   Sasaki Naomi N   Shimizu Daisuke D   Suzuki Gen G   Nakamura Satoaki S   Yamada Kei K   Okihara Koji K   Shiraishi Takumi T   Yoshida Ken K   Nishikawa Tatsuyuki T   Okabe Haruumi H  

Scientific reports 20180712 1


To compare the outcome of low-dose rate brachytherapy (LDR-BT) and image-guided intensity-modulated radiotherapy (IG-IMRT) for localized prostate cancer, we examined 488 LDR-BT and 269 IG-IMRT patients. IG-IMRT treated older and advanced disease with more hormonal therapy than LDR-BT, which excluded T3b-T4 tumor and initial PSA > 50 ng/ml. The actuarial five-year biochemical failure-free survival rate was 88.7% and 96.7% (p = 0.0003) in IG-IMRT and LDR-BT, respectively; it was 88.2% (85.1% for I  ...[more]

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