Differentiation of Alzheimer's disease based on local and global parameters in personalized Virtual Brain models.
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ABSTRACT:
SUBMITTER: Zimmermann J
PROVIDER: S-EPMC6051478 | biostudies-other | 2018
REPOSITORIES: biostudies-other
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Differentiation of Alzheimer's disease based on local and global parameters in personalized Virtual Brain models.
Zimmermann J J Perry A A Breakspear M M Schirner M M Sachdev P P Wen W W Kochan N A NA Mapstone M M Ritter P P McIntosh A R AR Solodkin A A
NeuroImage. Clinical 20180420
Alzheimer's disease (AD) is marked by cognitive dysfunction emerging from neuropathological processes impacting brain function. AD affects brain dynamics at the local level, such as changes in the balance of inhibitory and excitatory neuronal populations, as well as long-range changes to the global network. Individual differences in these changes as they relate to behaviour are poorly understood. Here, we use a multi-scale neurophysiological model, "The Virtual Brain (TVB)", based on empirical m ...[more]
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2015-07-29 | PXD000968 | Pride