Determining the optimal dose of atrasentan by evaluating the exposure-response relationships of albuminuria and bodyweight.

ABSTRACT: This study aimed to identify the optimal dose of the endothelin-1 receptor antagonist atrasentan with maximal albuminuria reduction and minimal signs of sodium retention, as manifested by increase in bodyweight. Data from the RADAR-JAPAN studies were used, evaluating the effect of 0.75 or 1.25?mg/d of atrasentan in 161 patients with type 2 diabetes and kidney disease. Individual pharmacokinetic parameters were estimated using a population pharmacokinetic approach. Subsequently, changes in the urinary albumin-to-creatinine ratio (UACR) and bodyweight from baseline after 2?weeks' exposure were modelled as a function of the pharmacokinetic parameters. The 0.75 and 1.25?mg doses showed a mean UACR reduction of 34.0% and 40.1%, whereas mean bodyweight increased by 0.9 and 1.1?kg, respectively. A large variation between individuals was observed in the UACR and bodyweight responses. Individual pharmacokinetic parameters correlated significantly with both individual UACR and bodyweight responses (P?

SUBMITTER: Koomen JV 

PROVIDER: S-EPMC6055665 | biostudies-other | 2018 Aug

REPOSITORIES: biostudies-other