Ontology highlight
ABSTRACT:
SUBMITTER: Pagar VV
PROVIDER: S-EPMC6055924 | biostudies-other | 2018 Jul
REPOSITORIES: biostudies-other
Pagar Vinayak Vishnu VV RajanBabu T V TV
Science (New York, N.Y.) 20180701 6397
Transformation of simple precursors into structurally complex cyclobutanes, present in many biologically important natural products and pharmaceuticals, is of considerable interest in medicinal chemistry. Starting from 1,3-enynes and ethylene, both exceptionally inexpensive starting materials, we report a cobalt-catalyzed route to vinylcyclobutenes, as well as the further enantioselective addition of ethylene to these products to form complex cyclobutanes with all-carbon quaternary centers. Thes ...[more]